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α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

13 Jul 2023

Abstract excerpt

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this interaction in normal and failing hearts remains unknown. Lactate is a crucial energy substrate of the heart. Here, we identify that α-MHC undergoes lactylation on lysine 1897 to regulate the interaction of α-MHC with Titin. We observed a reduction of α-MHC...

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PMID: 37443257
DOI: 10.1038/s41422-023-00844-w

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