Article

Lactate Metabolism in the Intervertebral Disc: Mechanistic Insights and Pathological Implications

2025-11-18

Abstract excerpt

Intervertebral disc (IVD), the largest avascular structure in the human body, contains nucleus pulposus (NP) cells that generate an abundant quantity of lactate from anaerobic glycolysis as an adaptation to hypoxia. Historically, IVD lactate was viewed as a metabolic toxic byproduct necessitating clearance to maintain IVD health. This is because accumulation of lactic acid, the protonated form of lactate, acidifie...

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Literature Corpus work: e8374fe3-e3d5-598d-8453-0486dabf8450
DOI: 10.20944/preprints202511.1321.v1

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