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Article

A panoramic analysis of keloid pathogenesis: multidimensional network regulation of genetics-immunity-metabolism-mechanical force.

Frontiers in immunology - 1 Jan 2026

Liu Mengguo

Abstract excerpt

Keloid, as a unique form of pathological scar, involves complex interactions across multiple dimensions in its pathogenesis, including genetic susceptibility, epigenetic regulation, immune microenvironment disorders, metabolic reprogramming, abnormal mechanical force transduction, and fine-tuning by non-coding RNAs. At the genetic level, alleles such as HLA-DRB1*15, HOX gene family, and high-frequency mutation...

Read the complete abstract on PubMed

Topics

Humans
Keloid
Epigenesis, Genetic
Signal Transduction
Animals
Mechanotransduction, Cellular
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cellular Microenvironment

Metabolic Reprogramming

Source

Open in PubMed Open full text

Identifiers

PMID: 42719615
DOI: 10.3389/fimmu.2026.1936809
PMCID: PMC13555381

Genes

COL1A1
CXCL12
MUC4
PIEZO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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