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Article

Single-nucleus multi-omics delineates distinct epigenetic programs associated with tumor progression in lung adenocarcinoma.

Clinical epigenetics - 11 Feb 2026

Kim Yeji, Kang Huiram, Hwang Yongki, Kim Kyung Soo, Moon Seok Whan, Kim Jeonghan, Kim Seung Joon, Lee Hae-Ock

Abstract excerpt

BACKGROUND: Lung adenocarcinoma (LUAD), the most prevalent type of lung cancer, displays marked molecular and cellular heterogeneity driven by diverse oncogenic alterations. Many of these changes are thought to occur during the transformation of alveolar type 2 (AT2) cells, which function as stem-like progenitors and likely cells of origin for LUAD. To investigate the regulatory mechanisms underlying AT2 cell...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 41673764
DOI: 10.1186/s13148-026-02078-0
PMCID: PMC13200395

Genes

ROS1
SLC34A2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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