Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting the shared genetic landscape of schizophrenia and hippocampal subfields: A genome-wide cross-trait analysis.

Translational psychiatry - 11 Feb 2026

Guo Lining, Zhao Jiaxuan, Qin Qin, Chen Yayuan, Sun Zuhao, Zhang Zhihui, Lei Minghuan, Zhai Ying, Xu Jinglei, Cai Wenjie, An Qi, Wu Yue, Wang Haolin, Li Fengtan, Peng Yanmin, Liu Mengge, Liu Feng

Abstract excerpt

Schizophrenia is associated with hippocampal volumetric changes, yet the genetic mechanisms linking schizophrenia to alterations in hippocampal volume and its subfields remain poorly understood. We analyzed the largest available GWAS summary statistics for schizophrenia (53,386 cases, 77,258 controls) and hippocampal volumetric traits (33,224 individuals). Linkage disequilibrium score regression (LDSC) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Linkage Disequilibrium

Share to Organ Size

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Source

Identifiers

PMID: 41672967
DOI: 10.1038/s41398-026-03897-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting the shared genetic landscape of schizophrenia and hippocampal subfields: A genome-wide cross-trait analysis.PMID 41672967Read ↗

Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.Semantic proximity Read ↗

Comprehensive analysis of shared genetic loci between hippocampal volume and schizophrenia.Semantic proximity Read ↗

A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype.Semantic proximity Read ↗

Brain Heterogeneity in Schizophrenia and Its Association With Polygenic RiskSemantic proximity Read ↗

Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.Semantic proximity Read ↗

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disordersSemantic proximity Read ↗

Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders.Semantic proximity Read ↗

Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.Semantic proximity Read ↗

The genetic relationships between brain structure and schizophrenia.Semantic proximity Read ↗

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.Semantic proximity Read ↗

Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology.Semantic proximity Read ↗

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.