Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4- mediated ferritinophagy as a dependence in Tet2 -deficient hematopoiesis

10 Jun 2025

Abstract excerpt

ABSTRACT: TET2 is among the most commonly mutated genes in both clonal hematopoiesis and myeloid malignancies; thus, the ability to identify selective dependencies in TET2-deficient cells has broad translational significance. Here, we identify regulators of Tet2 knockout (KO) hematopoietic stem and progenitor cell (HSPC) expansion using an in vivo CRISPR-Cas9 KO screen, in which nucleotide barcoding enabled...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40493884
DOI: 10.1182/blood.2024028033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4- mediated ferritinophagy as a dependence in Tet2 -deficient hematopoiesisPMID 40493884Read ↗

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.Semantic proximity Read ↗

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cellsSemantic proximity Read ↗

Can Ruxolitinib Crash TET2- and IDH2-Driven Clonal Hematopoiesis?Semantic proximity Read ↗

TET2 mutation as prototypic clonal hematopoiesis lesion.Semantic proximity Read ↗

TET2 is essential for survival and hematopoietic stem cell homeostasisSemantic proximity Read ↗

Comparative analysis of Tet2 catalytic-deficient and knockout bone marrow over time.Semantic proximity Read ↗

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.Semantic proximity Read ↗

RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in miceSemantic proximity Read ↗

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventionsSemantic proximity Read ↗

<i>Id1</i> Promotes Clonal Hematopoiesis in Mice with <i>Tet2</i> Loss of FunctionSemantic proximity Read ↗

<i>TET2</i> and <i>TP53</i> Mutations Cooperatively Modulate the Response to Inflammation to Promote Leukemic TransformationSemantic proximity Read ↗

Tet2 deficiency drives age-related heterogeneous progression of myeloid neoplasms through epigenetic-immune microenvironment imbalance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.