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Article

Restricted Versus Genome-Wide Genetic Risk Scores for Coronary Artery Disease.

Journal of the American Heart Association - 17 Feb 2026

Sedaghati-Khayat Bahar, Lin Henry J, Tan Jingyi, Yao Jie, Mazumdar Tapati, Bos Maxime, Juskiewicz Katherine, Broer Linda, Taylor Kent D, Li Xiaohui, van Meurs Joyce, Ikram M Arfan, Bartaria Shubhi, Post Wendy S, Sincan Murat, Uitterlinden André G, Guo Xiuqing, Hajek Catherine, Kavousi Maryam, van Rooij Jeroen, Rotter Jerome I

Abstract excerpt

BACKGROUND: Genetic risk scores may be useful for analyzing risks for coronary artery disease (CAD). However, comparisons between restricted and genome-wide scores have been underexplored, particularly for individuals at increased risk by one score but not the other. Here, we compared restricted polygenic risk scores with 181 high-confidence genetic variants (PRS181) and genome-wide risk scores that encompass 6.6...

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Identifiers

PMID: 41669951
DOI: 10.1161/JAHA.125.041398
PMCID: PMC13055487

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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