Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationship between genetically determined telomere length and childhood glioma risk.

Acta neuropathologica communications - 10 Feb 2026

Zhou Naying, Li Shaobo, Foss-Skiftesvik Jon, Dahlin Anna M, Bybjerg-Grauholm Jonas, Melin Beatrice, de Smith Adam J, Walsh Kyle M, Wiemels Joseph L

Abstract excerpt

While longer genetically predicted leukocyte telomere length (LTL) has been linked to increased glioma risk in adults, this association has not been investigated in pediatric populations. In this study, we applied Mendelian randomization (MR) and polygenic risk score (PRS) analyses to investigate the relationship between LTL and pediatric glioma risk, using 4,069 cases and 8,778 controls from the largest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Risk Score
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes

Share to Mendelian Randomization Analysis

Share to Shelterin Complex

Share to Telomere

Share to Telomere-Binding Proteins

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 41668119
DOI: 10.1186/s40478-025-02199-2
PMCID: PMC13085377

Genes

POT1
TERT
ZNF208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationship between genetically determined telomere length and childhood glioma risk.PMID 41668119Read ↗

Relationship between genetically determined telomere length and glioma risk.Semantic proximity Read ↗

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.Semantic proximity Read ↗

Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.Semantic proximity Read ↗

Telomere maintenance and the etiology of adult gliomaSemantic proximity Read ↗

Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.Semantic proximity Read ↗

Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.Semantic proximity Read ↗

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.Semantic proximity Read ↗

A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk.Semantic proximity Read ↗

Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.Semantic proximity Read ↗

Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.Semantic proximity Read ↗

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.Semantic proximity Read ↗

New insights into susceptibility to glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.