Article
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Carcinogenesis - 1 Jun 2016
Walsh Kyle M, Whitehead Todd P, de Smith Adam J, Smirnov Ivan V, Park Minsun, Endicott Alyson A, Francis Stephen S, Codd Veryan, Samani Nilesh J, Metayer Catherine, Wiemels Joseph L
Abstract excerpt
Aberrant telomere lengthening is an important feature of cancer cells in adults and children. In addition to somatic mutations, germline polymorphisms in telomere maintenance genes impact telomere length. Whether these telomere-associated polymorphisms affect risk of childhood malignancies remains largely unexplored. We collected genome-wide data from three groups with pediatric malignancies [neuroblastoma (N =...
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