Article
Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Neuro-oncology - 5 Sept 2023
Foss-Skiftesvik Jon, Li Shaobo, Rosenbaum Adam, Hagen Christian Munch, Stoltze Ulrik Kristoffer, Ljungqvist Sally, Hjalmars Ulf, Schmiegelow Kjeld, Morimoto Libby, de Smith Adam J, Mathiasen René, Metayer Catherine, Hougaard David, Melin Beatrice, Walsh Kyle M, Bybjerg-Grauholm Jonas, Dahlin Anna M, Wiemels Joseph L
Abstract excerpt
BACKGROUND: Although recent sequencing studies have revealed that 10% of childhood gliomas are caused by rare germline mutations, the role of common variants is undetermined and no genome-wide significant risk loci for pediatric central nervous system tumors have been identified to date. METHODS: Meta-analysis of 3 population-based genome-wide association studies comprising 4069 children with glioma and 8778...
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