Article
Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
Neuro-oncology - 1 Aug 2013
Walsh Kyle M, Rice Terri, Decker Paul A, Kosel Matthew L, Kollmeyer Thomas, Hansen Helen M, Zheng Shichun, McCoy Lucie S, Bracci Paige M, Anderson Erik, Hsuang George, Wiemels Joe L, Pico Alexander R, Smirnov Ivan, Molinaro Annette M, Tihan Tarik, Berger Mitchell S, Chang Susan M, Prados Michael D, Lachance Daniel H, Sicotte Hugues, Eckel-Passow Jeanette E, Wiencke John K, Jenkins Robert B, Wrensch Margaret R
Abstract excerpt
BACKGROUND: Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function. We examined associations of these 7 established glioma risk loci with age at diagnosis among p...
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