Article
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
Acta neuropathologica communications - 28 Oct 2020
Zhang Chenan, Ostrom Quinn T, Semmes Eleanor C, Ramaswamy Vijay, Hansen Helen M, Morimoto Libby, de Smith Adam J, Pekmezci Melike, Vaksman Zalman, Hakonarson Hakon, Diskin Sharon J, Metayer Catherine, Taylor Michael D, Wiemels Joseph L, Bondy Melissa L, Walsh Kyle M
Abstract excerpt
Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influences ependymoma risk, we utilized case-control data from three studies: a population-based pediatric and adolescent ependymoma case-control sample from California (153 cases,...
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