Article
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
Nature genetics - 1 Jul 2014
Walsh Kyle M, Codd Veryan, Smirnov Ivan V, Rice Terri, Decker Paul A, Hansen Helen M, Kollmeyer Thomas, Kosel Matthew L, Molinaro Annette M, McCoy Lucie S, Bracci Paige M, Cabriga Belinda S, Pekmezci Melike, Zheng Shichun, Wiemels Joseph L, Pico Alexander R, Tihan Tarik, Berger Mitchell S, Chang Susan M, Prados Michael D, Lachance Daniel H, O'Neill Brian Patrick, Sicotte Hugues, Eckel-Passow Jeanette E, van der Harst Pim, Wiencke John K, Samani Nilesh J, Jenkins Robert B, Wrensch Margaret R
Abstract excerpt
Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with...
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