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Article

Rapid Adaptive Evolution under Combination Therapy in Klebsiella pneumoniae.

ACS infectious diseases - 8 May 2026

de Souza Camila Maurmann, Lee Amy, Martínez Osmel Fleitas, Ning Kevin, da Costa Mylena Cardoso, Maximiano Mariana Rocha, Feitosa Gabriel Cidade, Neiva Yasmim, Campos Marcelo, Ramada Marcelo, Alencar Sérgio, Hancock Robert E W, Franco Octávio Luiz

Abstract excerpt

Klebsiella pneumoniae poses a substantial health concern worldwide, with high mortality often associated with its elevated resistance levels. Combination antibiotic therapies have emerged as a viable strategy for addressing infections caused by these highly resistant pathogens, yet the evolutionary routes to resistance under such regimens remain poorly understood. Here, we investigated how resistance can emerge...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41665187
DOI: 10.1021/acsinfecdis.5c00934
PMCID: PMC13162261

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