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Article

Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants.

BMC medicine - 10 Feb 2026

Wang Xuemin, Dossus Laure, Gunter Marc J, Davidson Emma J, Ong Jue-Sheng, Glubb Dylan M, O'Mara Tracy A

Abstract excerpt

BACKGROUND: Although obesity is a well-established risk factor for endometrial cancer, its relationship with genetic susceptibility in determining cancer risk remains unexplored. Current endometrial cancer risk prediction relies primarily on epidemiological factors, with limited consideration of genetic risk. We hypothesized that integrating polygenic risk score (PRS) information with established epidemiological...

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Identifiers

PMID: 41664190
DOI: 10.1186/s12916-025-04570-5
PMCID: PMC12888353

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