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Article

The Tumor Multi-Omic Landscape of Endometrial Cancers Developed on a Background of Adiposity.

Genes - 29 Jun 2026

Richenberg George, Francis Amy, Owen Carina N, Gray Victoria, Robinson Timothy, Gabriel Aurélie A G, Lawrenson Kate, Davidson Emma J, Schildkraut Joellen M, Mckay James D, Gaunt Tom R, Relton Caroline L, Vincent Emma E, Kar Siddhartha P

Abstract excerpt

Background: High body mass index (BMI) is a causal risk factor for endometrial cancer, but the tumor molecular mechanisms affected by adiposity remain poorly understood. Here, we characterize the tumor multi-omic landscape of endometrial cancers that have developed on a background of lifelong germline genetic liability to elevated BMI. Methods: We built a polygenic score (PGS) for BMI in women using data on...

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Share to Adiposity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Risk Score

Share to Genome-Wide Association Study

Share to Multiomics

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 42510784
DOI: 10.3390/genes17070744
PMCID: PMC13408957

Genes

IL6
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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The Tumor Multi-Omic Landscape of Endometrial Cancers Developed on a Background of Adiposity.PMID 42510784Read ↗

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Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million womenSemantic proximity Read ↗

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