Article
Polygenic risk score opportunities for early detection and prevention strategies in endometrial cancer.
British journal of cancer - 1 Sept 2020
O'Mara Tracy A, Crosbie Emma J
Abstract excerpt
Recent large-scale genetic studies, particularly genome-wide association studies (GWAS), have emphasised the importance of common genetic variation in endometrial cancer susceptibility. Although each of these variants only confer modest effects on endometrial cancer risk, together they are likely to explain a substantial amount of the familial relative risk of the disease. Therefore, methods to combine genetic...
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