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Article

Development and evaluation of polygenic risk scores for prediction of endometrial cancer risk in European women.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2022

Bafligil Cemsel, Thompson Deborah J, Lophatananon Artitaya, Ryan Neil A J, Smith Miriam J, Dennis Joe, Mekli Krisztina, O'Mara Tracy A, Evans D Gareth, Crosbie Emma J

Abstract excerpt

PURPOSE: Single-nucleotide variations (SNVs) (formerly single-nucleotide polymorphism [SNV]) influence genetic predisposition to endometrial cancer. We hypothesized that a polygenic risk score (PRS) comprising multiple SNVs may improve endometrial cancer risk prediction for targeted screening and prevention. METHODS: We developed PRSs from SNVs identified from a systematic review of published studies and...

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Identifiers

PMID: 35704044
DOI: 10.1016/j.gim.2022.05.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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