Article
Constructing a multi-ancestry polygenic risk score for uterine fibroids using publicly available data highlights need for inclusive genetic research.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2025
Winters Jessica L G, Piekos Jacqueline A, Hellwege Jacklyn N, Dikilitas Ozan, Kullo Iftikhar J, Schaid Daniel J, Edwards Todd L, Velez Edwards Digna R
Abstract excerpt
Uterine leiomyomata, or fibroids, are common gynecological tumors causing pelvic and menstrual symptoms that can negatively affect quality of life and child-bearing desires. As fibroids grow, symptoms can intensify and lead to invasive treatments that are less likely to preserve fertility. Identifying individuals at highest risk for fibroids can aid in access to earlier diagnoses. Polygenic risk scores (PRS)...
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