Article

The tumor multi-omic landscape of endometrial cancers developed on a germline genetic background of adiposity

2023-10-10

Abstract excerpt

<h4>ABSTRACT</h4> High body mass index (BMI) is a causal risk factor for endometrial cancer but the tumor molecular mechanisms affected by adiposity and their therapeutic relevance remain poorly understood. Here we characterize the tumor multi-omic landscape of endometrial cancers that have developed on a background of lifelong germline genetic exposure to elevated BMI. We built a polygenic score (PGS) for BMI in...

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Literature Corpus work: c0115396-f494-52ed-a068-d9625c2662ae
DOI: 10.1101/2023.10.09.23296765

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