Article
Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.
BMC medicine - 19 Apr 2022
Hazelwood Emma, Sanderson Eleanor, Tan Vanessa Y, Ruth Katherine S, Frayling Timothy M, Dimou Niki, Gunter Marc J, Dossus Laure, Newton Claire, Ryan Neil, Pournaras Dimitri J, O'Mara Tracy A, Davey Smith George, Martin Richard M, Yarmolinsky James
Abstract excerpt
BACKGROUND: Endometrial cancer is the most common gynaecological cancer in high-income countries. Elevated body mass index (BMI) is an established modifiable risk factor for this condition and is estimated to confer a larger effect on endometrial cancer risk than any other cancer site. However, the molecular mechanisms underpinning this association remain unclear. We used Mendelian randomization (MR) to evaluate...
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