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Elucidating the causal relationships between cerebrospinal fluid metabolites and glioblastoma insights from mendelian randomization study.

Neurosurgical review - 7 Feb 2026

Yan Chengrui, Wang Bin, Shi Guangchao, Ma Wenbin, Li Kai

Abstract excerpt

BACKGROUND: The cerebrospinal fluid (CSF) metabolites could potentially direct reflecting the biochemical processes involved in central nervous system metabolism. This study aims to delineate the potential causal relationships between CSF metabolites and Glioblastoma (GBM) using Mendelian Randomization (MR) analysis. METHODS: This research employs a two-sample MR framework, utilizing genetic instrumental...

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PMID: 41653332
DOI: 10.1007/s10143-025-04103-x

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