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Mendelian randomization study of causal link from Cerebrospinal fluid metabolomics to neurodegenerative diseases.

Neurogenetics - 6 Dec 2024

Zhang Jingjing, Zhang Xin, Xiao Boan, Ouyang Jiecai, Wang Peng, Peng Xiaobin

Abstract excerpt

To investigate the causal relationships between cerebrospinal fluid (CSF) metabolites and various neurodegenerative diseases (NDDs), we conducted a two-sample Mendelian randomization (MR) analysis. This study utilized summary statistics from genome-wide association studies (GWAS) of CSF metabolites and four common neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis...

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PMID: 39641862
DOI: 10.1007/s10048-024-00792-6

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