Article
The role of cerebrospinal fluid metabolites in the pathogenesis of lung adenocarcinoma: An observational study using Mendelian randomization.
Medicine - 26 Sept 2025
Zhu Xingcheng, Fu Yuanzhi, Zhu Lin, Liu Rongyuan, Li Dongqing, Zhao Junxian, Chen Weiwen, Chen Junhao
Abstract excerpt
The causal relationship between Cerebrospinal fluid (CSF) and lung adenocarcinoma (LUAD) is still uncertain. This study aims to identify the genetically predicted causality of CSF on LUAD through Mendelian randomization (MR). This study utilized a two-sample MR approach to examine the causal relationship between CSF metabolites and LUAD. Data for LUAD was obtained from a large genome-wide association study (GWAS)...
Read the complete abstract on PubMedTopics
- Humans
- Mendelian Randomization Analysis
- Adenocarcinoma of Lung
- Lung Neoplasms
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide