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Multi-omics analysis of perfluorooctanoic acid and glioblastoma: insights from Mendelian randomization, network toxicology, and molecular docking.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2026

Yang Xiaonan, Xiong Junpeng, Zhang Chenao, Wang Han

Abstract excerpt

Glioblastoma (GBM) is the most lethal primary brain tumor with limited treatment options. Perfluorooctanoic acid (PFOA), a ubiquitous "forever chemical" classified as a group 1 carcinogen by the IARC, can cross the blood-brain barrier and accumulate in neural tissue. This study aimed to determine the causal relationship between genetically predicted higher circulating PFOA levels and GBM risk, elucidate...

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Identifiers

PMID: 41984189
DOI: 10.1007/s00210-026-05285-x

Genes

MYC
TNF
ALB
BCL2
CASP3
EGFR
ESR1
IL1B
IL6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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