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Article

Cerebrospinal fluid and plasma metabolites in Parkinson's disease: a Mendelian randomization study.

Scientific reports - 23 Mar 2026

Wang Jia-Li, Zhao Qianhui, Zheng Ran, Fang Yi, Cao Jin, Zhang Bao-Rong

Abstract excerpt

Metabolites in cerebrospinal fluid (CSF) and plasma have been implicated in Parkinson's disease (PD), but their causal roles remain unclear. This study aims to investigate the causal relationships between specific CSF and plasma metabolites and PD risk, using Mendelian Randomization (MR) analysis. We utilized MR with inverse-variance weighting (IVW) as the primary analytical method, supplemented by four...

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Identifiers

PMID: 41872227
DOI: 10.1038/s41598-025-30521-4
PMCID: PMC13009158

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