Article
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.
The Journal of clinical investigation - 1 Jul 2021
Lopez-Ramirez Miguel Alejandro, Lai Catherine Chinhchu, Soliman Shady Ibrahim, Hale Preston, Pham Angela, Estrada Esau J, McCurdy Sara, Girard Romuald, Verma Riya, Moore Thomas, Lightle Rhonda, Hobson Nicholas, Shenkar Robert, Poulsen Orit, Haddad Gabriel G, Daneman Richard, Gongol Brendan, Sun Hao, Lagarrigue Frederic, Awad Issam A, Ginsberg Mark H
Abstract excerpt
Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 (CCM3), and generally regarded as an endothelial cell-autonomous disease. Here we reported that proliferative astrocytes played a critical role in CCM pathogenesis by serving as a major source of VEGF during CCM lesion formation. An increase in...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Astrocytes
- Cyclooxygenase 2
- Disease Models, Animal
- Disease Progression
- Endothelial Cells
- Hemangioma, Cavernous, Central Nervous System