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Article

Thermally activated history-dependent homogenization of G-quadruplexes in an ALS/FTD-associated gene.

Biophysical journal - 17 Mar 2026

Ross Daniel, Lewis Olivia, McLean Olivia, Bhanot Sundeep, Donahue Shane, Baker Rachael, Dias Randi, Eagerton David, Mohanty Vaibhav, Mohanty Bidyut K

Abstract excerpt

A significant proportion of familial amyotrophic lateral sclerosis and frontotemporal dementia cases exhibit a substantial copy number expansion of the hexanucleotide GGGGCC/GGCCCC sequence in the C9ORF72 gene. The GGGGCC sequence forms a noncanonical DNA structure called a G-quadruplex (G4), which has been associated with the disease states and with nucleic acid condensate formation. G4s can fold into various...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41640102
DOI: 10.1016/j.bpj.2026.01.054
PMCID: PMC13351970

Genes

C9ORF72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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