Article

Fast MAS NMR Spectroscopy Can Identify G-Quartets and Double-Stranded Structures in Aggregates Formed by GGGGCC RNA Repeats

2025-09-12

Abstract excerpt

The expansion of GGGGCC repeats within the C9orf72 gene has been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In neurons from patients with expanded repeats, C9orf72 GGGGCC repeat RNA predominantly forms nuclear foci, and in vitro , repeat-containing RNA can self-aggregate. Two structural motifs have been proposed to provide the interstrand interactions that drive aggregation...

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Literature Corpus work: 97d959ca-a8b6-554f-9c2f-c9f2e16e1184
DOI: 10.1101/2025.09.07.674584

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