Article

Quantifying Structural Diversity of CNG Trinucleotide Repeats Using Diagrammatic Algorithms

2020-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Trinucleotide repeat expansion disorders (TREDs) exhibit complex mechanisms of pathogenesis, some of which have been attributed to RNA transcripts of overexpanded CNG repeats, resulting in possibly a gain-of-function. In this paper, we aim to probe the structures of these expanded transcript by analyzing the structural diversity of their conformational ensembles. We used graphs to catalog the st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d59e286-216b-50b7-9e0c-5add5ab418c5
DOI: 10.1101/2020.05.30.124636

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantifying Structural Diversity of CNG Trinucleotide Repeats Using Diagrammatic AlgorithmsDOI 10.1101/2020.05.30.124636Read

Thermodynamic Stability of RNA Structures Formed by CNG Trinucleotide Repeats. Implication for Prediction of RNA StructureSemantic proximity Read

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.Semantic proximity Read

Trinucleotide expansion in disease: why is there a length threshold?Semantic proximity Read

Structures of trinucleotide repeats in human transcripts and their functional implications.Semantic proximity Read

ALS and FTD linked GGGGCC-repeat containing DNA oligonucleotide folds into two distinct G-quadruplexes.Semantic proximity Read

RNA structure of trinucleotide repeats associated with human neurological diseases.Semantic proximity Read

Mechanisms of DNA expansion.Semantic proximity Read

Thermally activated irreversible homogenization of G-quadruplexes in an ALS/FTD-associated geneSemantic proximity Read

Structural Diversity of Triplet Repeat RNAsSemantic proximity Read

The CGG triplet repeat binding protein 1 counteracts DNA secondary structure-induced transcription-replication conflictsSemantic proximity Read

RNA phase transitions in repeat expansion disordersSemantic proximity Read

<i>RFC1</i> AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVASSemantic proximity Read