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Article

CR2-fH, A Targeted Inhibitor of Alternative Complement Pathway Reduces Dry AMD-Like Phenotype in AMD Patient iPSC-derived RPE Cells.

Investigative ophthalmology & visual science - 2 Feb 2026

Navneet Soumya, Rohrer Bärbel

Abstract excerpt

Purpose: To investigate whether the alternative pathway (AP) of complement inhibition restores the epithelial phenotype and ameliorates dry AMD biomarkers in AMD patient induced pluripotent stem cell-derived RPE (iPSC-RPE) monolayers. Methods: iPSC-RPE monolayers were established from an AMD patient iPSC line; ARPE-19 monolayers were used for comparison. For AP inhibition, monolayers were treated with CR2-fH...

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Share to Cells, Cultured
Share to Complement Factor H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Pathway, Alternative

Share to Induced Pluripotent Stem Cells

Share to Macular Degeneration

Share to Receptors, Complement 3d

Share to Retinal Pigment Epithelium

Share to Zonula Occludens-1 Protein

Source

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Identifiers

PMID: 41631752
DOI: 10.1167/iovs.67.2.9
PMCID: PMC12882102

Genes

RPE
CR2
RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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