Article

Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway

2017-07-03

Abstract excerpt

<h4>ABSTRACT</h4> The design of efficient therapies for age-related macular degeneration (AMD) is limited by our understanding of the pathogenesis of basal deposits, which form between retinal pigment epithelium (RPE) and Bruch’s membrane (BrM) early in disease, and involve activation of the complement system. To investigate the roles of BrM, RPE and complement in AMD, we generated ARPE-19 cells with the p.R345W...

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Literature Corpus work: 9cbe7120-d5ef-5534-9690-a36f7ec43d8c
DOI: 10.1101/152835

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