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Article

Increased plasma level of terminal complement complex in AMD patients: potential functional consequences for RPE cells.

Frontiers in immunology - 1 Jan 2023

Busch Catharina, Rau Saskia, Sekulic Andjela, Perie Luce, Huber Christian, Gehrke Miranda, Joussen Antonia M, Zipfel Peter F, Wildner Gerhild, Skerka Christine, Strauß Olaf

Abstract excerpt

Purpose: Polymorphisms in complement genes are risk-associated for age-related macular degeneration (AMD). Functional analysis revealed a common deficiency to control the alternative complement pathway by risk-associated gene polymorphisms. Thus, we investigated the levels of terminal complement complex (TCC) in the plasma of wet AMD patients with defined genotypes and the impact of the complement activation of...

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Identifiers

PMID: 37359546
DOI: 10.3389/fimmu.2023.1200725
PMCID: PMC10287163

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