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Article

Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.

The Journal of biological chemistry - 28 Mar 2014

Radu Roxana A, Hu Jane, Jiang Zhichun, Bok Dean

Abstract excerpt

Age-related macular degeneration (AMD) is a common central blinding disease of the elderly. Homozygosity for a sequence variant causing Y402H and I62V substitutions in the gene for complement factor H (CFH) is strongly associated with risk of AMD. CFH, secreted by many cell types, including those of the retinal pigment epithelium (RPE), is a regulatory protein that inhibits complement activation. Recessive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24550392
DOI: 10.1074/jbc.M114.548669
PMCID: PMC3979386

Genes

CFH
RPE
ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.PMID 24550392Read ↗

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.Semantic proximity Read ↗

Bruch’s Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular DegenerationSemantic proximity Read ↗

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