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Article

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells.

Frontiers in immunology - 1 Jan 2021

Schäfer Nicole, Rasras Anas, Ormenisan Delia M, Amslinger Sabine, Enzmann Volker, Jägle Herbert, Pauly Diana

Abstract excerpt

Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD). However, the non-canonical local, cellular functions of FHR-3 remained poorly understood. Here, we report that FHR-3 bound to oxidative stress epitopes and competed with FH for interaction. Furthermore, FHR-3 was internalized by viable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34819935
DOI: 10.3389/fimmu.2021.769242
PMCID: PMC8606654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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