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Article

Additive Value of Polygenic Risk Score to Family History for Type 2 Diabetes Prediction: Results From the All of Us Research Database.

Diabetes care - 1 Feb 2025

Drzymalla Emily, Raffield Laura, Kolor Katherine, Koyama Alain, Moonesinghe Ramal, Pavkov Meda E, Spracklen Cassandra N, Khoury Muin J

Abstract excerpt

OBJECTIVE: The goal of this study was to assess the additive value of considering type 2 diabetes (T2D) polygenic risk score (PRS) in addition to family history for T2D prediction. RESEARCH DESIGN AND METHODS: Data were obtained from the All of Us (AoU) research database. First-degree T2D family history was self-reported on the personal family history health questionnaire. A PRS was constructed from 1,289...

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Identifiers

PMID: 39841967
DOI: 10.2337/dc24-1537
PMCID: PMC11770167

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