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Article

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.

Journal of lipid research - 1 Dec 2014

Obinata Hideru, Gutkind Sarah, Stitham Jeremiah, Okuno Toshiaki, Yokomizo Takehiko, Hwa John, Hla Timothy

Abstract excerpt

Sphingosine 1-phosphate receptor 1 (S1P₁), an abundantly-expressed G protein-coupled receptor which regulates key vascular and immune responses, is a therapeutic target in autoimmune diseases. Fingolimod/Gilenya (FTY720), an oral medication for relapsing-remitting multiple sclerosis, targets S1P₁ receptors on immune and neural cells to suppress neuroinflammation. However, suppression of endothelial S1P₁ receptors...

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Identifiers

PMID: 25293589
DOI: 10.1194/jlr.P054163
PMCID: PMC4242458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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