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GLP1R (glucagon-like-peptide-1 incretin receptor), diabetes and obesity phenotypes: An in silico approach revealed new pathogenic variants.

Diabetes & metabolic syndrome - 1 Feb 2024

Knihs Vinicius Matheus, Filippin-Monteiro Fabíola Branco

Abstract excerpt

OBJECTIVE: Glucagon-like peptide-1 receptor belongs to the B family of G protein-coupled receptors, serving as a binding protein in membranes and is widely expressed in human tissues. Upon stimulation by its agonist, the glucagon-like peptide-1, the receptor plays a role in glucose metabolism, enhancing insulin secretion, and regulating appetite in the hypothalamus. Mutations in the glucagon-like peptide-1...

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PMID: 38364583
DOI: 10.1016/j.dsx.2024.102956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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