In-Silico Investigation of Effects of Single-Nucleotide Polymorphisms in PCOS-Associated CYP11A1 Gene on Mutated Proteins.

doi:10.3390/genes13071231

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Article

In-Silico Investigation of Effects of Single-Nucleotide Polymorphisms in PCOS-Associated CYP11A1 Gene on Mutated Proteins.

Genes - 12 Jul 2022

Muccee Fatima, Bijou Osama, Harakeh Steve, Adawiyah Rabi'atul, Sayyed R Z, Haghshenas Leila, Alshehri Dikhnah, Ansari Mohammad Javed, Ghazanfar Shakira

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a reproductive disorder with multiple etiologies, mainly characterized by the excess production of androgens. It is equally contributed to by genes and environment. The CYP11A1 gene is imperative for steroidogenesis, so any dysregulation or mutation in this gene can lead to PCOS pathogenesis. Therefore, nucleotide diversity in this gene can be helpful in spotting the likelihood...

Topics

Female
Humans
Ataxia Telangiectasia Mutated Proteins
Cholesterol Side-Chain Cleavage Enzyme
Exons
Polycystic Ovary Syndrome
Polymorphism, Single Nucleotide

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PMID: 35886014
DOI: 10.3390/genes13071231
PMCID: PMC9317558

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