Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 controls COX assembly through regulation of redox status of mitochondrial copper chaperones.

Redox biology - 1 Mar 2026

Kim Tae Young, Jang Eun-Hae, Bae Yun-Hee, Hur Eun-Mi, Lee Byoung Dae

Abstract excerpt

Mitochondrial dysfunction is a common pathological hallmark of neurodegenerative diseases. In Parkinson's disease (PD), the most popular age-related movement disorder, the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is closely associated with mitochondrial energetic deficits, reflecting their exceptionally high metabolic demand. The electron transport chain (ETC),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Copper
Share to Electron Transport Complex IV
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Proteins

Share to Molecular Chaperones

Share to Oxidation-Reduction

Share to Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 41621246
DOI: 10.1016/j.redox.2026.104061
PMCID: PMC12882647

Genes

COX19
COX11
SCO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 controls COX assembly through regulation of redox status of mitochondrial copper chaperones.PMID 41621246Read ↗

LRRK2 mutations: at the crossroads of dopamine, iron, and calcium imbalance in Parkinson's disease.Semantic proximity Read ↗

From cell death to neurological disease: Unraveling the role of copperSemantic proximity Read ↗

The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic NeuronsSemantic proximity Read ↗

The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic NeuronsSemantic proximity Read ↗

A neuropsychiatric disease-associated mutation in LRRC8B disrupts cellular Ca²⁺ signaling, mitochondrial function, and bioenergeticsSemantic proximity Read ↗

Import, maturation, and function of SOD1 and its copper chaperone CCS in the mitochondrial intermembrane space.Semantic proximity Read ↗

Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal ModelsSemantic proximity Read ↗

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinomaSemantic proximity Read ↗

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathologySemantic proximity Read ↗

APOE expression and secretion are modulated by mitochondrial dysfunction.Semantic proximity Read ↗

<i>Cerox1</i> and microRNA-488-3p noncoding RNAs jointly regulate mitochondrial complex I catalytic activitySemantic proximity Read ↗

Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.