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Article

Dynamic consequences of threonine mutations in the CaLM motif of RET/GFRα1/GDNF ternary complex.

Journal of molecular graphics & modelling - 1 May 2026

R Bithia, C George Priya Doss

Abstract excerpt

The extracellular domain (ECD) of the RET receptor tyrosine kinase depends on its cysteine-rich domain (CRD) for calcium coordination, structural stability, and assembly with GFRα1 and GDNF. Mutations close to the CRD CaLM motif have been associated with disease, but their molecular effects remain understudied. In this study, we analyzed two clinically reported variants, T564N and T564P, using all-atom molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41616695
DOI: 10.1016/j.jmgm.2026.109301

Genes

RET
GDNF
ECD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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