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Article

Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase.

Physical chemistry chemical physics : PCCP - 28 Mar 2016

Gao Chunxia, Grøtli Morten, Eriksson Leif A

Abstract excerpt

Mutations in the rearranged during transfection (RET) tyrosine kinase gene leading to gain or loss of function have been associated with the development of several human cancers and Hirschsprung's disease (HSCR). However, to what extent these mutations affect individual bio-molecular functions remains unclear. In this article, the functionally significant mutations in the RET CLD1-4 calcium-binding site which...

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Source

Identifiers

PMID: 26950000
DOI: 10.1039/c6cp00042h

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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