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Article

Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.

Cancer research - 17 Oct 2022

Tabata Junya, Nakaoku Takashi, Araki Mitsugu, Yoshino Ryunosuke, Kohsaka Shinji, Otsuka Ayaka, Ikegami Masachika, Ui Ayako, Kanno Shin-Ichiro, Miyoshi Keiko, Matsumoto Shigeyuki, Sagae Yukari, Yasui Akira, Sekijima Masakazu, Mano Hiroyuki, Okuno Yasushi, Okamoto Aikou, Kohno Takashi

Abstract excerpt

Distinguishing oncogenic mutations from variants of unknown significance (VUS) is critical for precision cancer medicine. Here, computational modeling of 71,756 RET variants for positive selection together with functional assays of 110 representative variants identified a three-dimensional cluster of VUSs carried by multiple human cancers that cause amino acid substitutions in the calmodulin-like motif (CaLM) of...

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Identifiers

PMID: 36166639
DOI: 10.1158/0008-5472.CAN-22-0834
PMCID: PMC9574375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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