Article
In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach.
Molecular bioSystems - 4 Mar 2014
George Priya Doss C, Rajith B, Chakraboty Chiranjib, Balaji V, Magesh R, Gowthami B, Menon Sneha, Swati M, Trivedi Manjari, Paul Jasmine, Vasan Richa, Das Maitreya
Abstract excerpt
A major challenge remaining in drug design efforts towards protein kinase is due to the development of drug resistance initiated by the missense mutations in the kinase catalytic domain. Gain or loss of function mutations in the REarranged during Transfection (RET) tyrosine kinase gene have been associated with the development of a wide range of human associated cancers and Hirschsprung's disease. However, to...
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