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Article

Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.

Biophysical journal - 1 Feb 2009

Dixit Anshuman, Torkamani Ali, Schork Nicholas J, Verkhivker Gennady

Abstract excerpt

Structural and biochemical characterization of protein kinases that confer oncogene addiction and harbor a large number of disease-associated mutations, including RET and MET kinases, have provided insights into molecular mechanisms associated with the protein kinase activation in human cancer. In this article, structural modeling, molecular dynamics, and free energy simulations of a structurally conserved...

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Source

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Identifiers

PMID: 19186126
DOI: 10.1016/j.bpj.2008.10.041
PMCID: PMC2716637

Genes

RET
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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