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Genetic Determinants of Peanut-Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study.

Immunology - 1 Jun 2026

Kanchan Kanika, Cerosaletti Karen, Perry James A, DuToit George, Manohar Monali, Ling Hua, Paschall Justin E, Sanda Srinath, Chinthrajah R Sharon, Nepom Gerald T, Nadeau Kari C, Jones Stacie M, Lack Gideon, Ruczinski Ingo, Mathias Rasika A

Abstract excerpt

In the Learning Early About Peanut Allergy (LEAP) study, participants in the peanut consumption group, at 60 months of age, had higher levels of peanut-specific IgG4 (psIgG4), a biomarker of immune modulation, compared to those in the peanut-avoidance group. We investigated the genetic determinants of psIgG4 among participants who consumed peanuts. Using whole-genome sequencing data, we performed a genome-wide...

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PMID: 41615410
DOI: 10.1111/imm.70098
PMCID: PMC13135883

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