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Article

Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy.

The Journal of allergy and clinical immunology - 1 Apr 2023

Huffaker Michelle F, Kanchan Kanika, Bahnson Henry T, Ruczinski Ingo, Shankar Gautam, Leung Donald Y M, Baloh Carolyn, Du Toit George, Lack Gideon, Nepom Gerald T, Mathias Rasika A

Abstract excerpt

BACKGROUND: Deleterious variation in the epidermal differentiation complex (EDC) on chromosome 1 is a well-known genetic determinant of atopic dermatitis (AD) and has been associated with risk of peanut allergy (PA) in population-based studies. OBJECTIVE: Our aim was to determine the effect of genetic variation in the EDC on AD trajectory and risk of PA in early life. METHODS: Genome sequencing was used to...

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Identifiers

PMID: 36403663
DOI: 10.1016/j.jaci.2022.11.008

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