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Article

Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells

22 Jul 2025

Abstract excerpt

ABSTRACT Background Oral immunotherapy (OIT) induces desensitization in peanut allergy, yet 15%–30% of patients do not respond, and a significant risk of anaphylaxis due to treatment remains. In a placebo‐controlled peanut OIT trial, this study identifies molecular drivers of OIT responsiveness through multi‐omics profiling in immune cells. Methods Immunoglobulins, cytokines, transcriptome, and DNA methylome...

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PMID: 40693699
DOI: 10.1111/all.16627

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