Article
HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.
The Journal of clinical investigation - 4 Jan 2022
Kanchan Kanika, Grinek Stepan, Bahnson Henry T, Ruczinski Ingo, Shankar Gautam, Larson David, Du Toit George, Barnes Kathleen C, Sampson Hugh A, Suarez-Farinas Mayte, Lack Gideon, Nepom Gerald T, Cerosaletti Karen, Mathias Rasika A
Abstract excerpt
We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an association between peanut-specific IgG4 and HLA-DQA1*01:02 that was only observed in the presence of sustained oral peanut protein exposure. The association between IgG4 and HLA-DQA1*01:02 was...
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