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Article

Epigenetic programming underpins B‐cell dysfunction in peanut and multi‐food allergy

1 Jan 2021

Abstract excerpt

OBJECTIVE: Rates of IgE-mediated food allergy (FA) have increased over the last few decades, and mounting evidence implicates disruption of epigenetic profiles in various immune cell types in FA development. Recent data implicate B-cell dysfunction in FA; however, few studies have examined epigenetic changes within these cells. METHODS: We assessed epigenetic and transcriptomic profiles in purified B cells from...

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PMID: 34466226
DOI: 10.1002/cti2.1324

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